TREATMENT PLANNING FOR I-131 METAIODOBENZYLGUANIDINE RADIOTHERAPY OF NEURAL CREST TUMORS USING I-124 METAIODOBENZYLGUANIDINE POSITRON EMISSION TOMOGRAPHY

被引：62

作者：

OTT, RJ

TAIT, D

FLOWER, MA

BABICH, JW

LAMBRECHT, RM

机构：

[1] INST CANC RES,DEPT RADIOTHERAPY,SUTTON SM2 5PX,SURREY,ENGLAND

[2] ROYAL MARSDEN HOSP,SUTTON,SURREY,ENGLAND

[3] MASSACHUSETTS GEN HOSP,DIV NUCL MED,BOSTON,MA 02114

[4] LUCAS HTS RES LABS,SYDNEY,AUSTRALIA

来源：

BRITISH JOURNAL OF RADIOLOGY | 1992年 / 65卷 / 777期

关键词：

NEURAL CREST TUMORS; METAIODOBENZYLGUANIDINE THERAPY; PET;

D O I：

10.1259/0007-1285-65-777-787

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Patients designated to receive I-131-meta-iodobenzylguanadine (mIBG) for the treatment of neural crest tumours have been scanned with I-124-mIBG using the MUP-PET positron camera. Uptake was detected in tumour sites in lung, liver and abdomen. The tomographic images produced have allowed estimates to be made of the concentration of mIBG in both tumour and normal tissue. From these data it is possible to predict the radiation doses that would be achieved using therapy levels (up to 11 GBq) of I-131-mIBG. The levels of tumour uptake are between 0.5 and 2.0 kBq/g indicating that the radiation doses to tumour would be in the range 3 Gy to 7.5 Gy.

引用

页码：787 / 791

页数：5

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