THEONEGRAMIDE, AN ANTIFUNGAL GLYCOPEPTIDE FROM THE PHILIPPINE LITHISTID SPONGE THEONELLA-SWINHOEI

被引：91

作者：

BEWLEY, CA ^{[1
]}

FAULKNER, DJ ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,SCRIPPS INST OCEANOG,LA JOLLA,CA 92093

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1994年 / 59卷 / 17期

关键词：

D O I：

10.1021/jo00096a028

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Theonegramide (2) is an antifungal glycopeptide consisting of arabinose joined to a bicyclic dodecapeptide that contains the unusual amino acids beta-hydroxyasparagine, isoserine, alpha-aminoadipic acid, 4'-bromo-3-methylphenylalanine,3-amino-4-hydroxy-6-methyl-8-phenylocta-5,7-dienoic acid, and the same histidinoalanine moiety previously observed in theonellamide F (1). The structure of theonegramide (2) was elucidated by analysis of spectral data and its absolute configuration was determined by GC-MS analysis using a chiral column packing.

引用

页码：4849 / 4852

页数：4

共 11 条

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