ABDOMINAL-SURGERY INDUCES C-FOS EXPRESSION IN THE NUCLEUS OF THE SOLITARY TRACT IN THE RAT

被引：32

作者：

ZITTEL, TT

DEGIORGIO, R

BRECHA, NC

STERNINI, C

RAYBOULD, HE

机构：

[1] W LOS ANGELES MED CTR,DEPT VET AFFAIRS,CTR ULCER RES & EDUC RES & MED SERV,LOS ANGELES,CA

[2] UNIV CALIF LOS ANGELES,SCH MED,DEPT MED,LOS ANGELES,CA 90024

[3] UNIV CALIF LOS ANGELES,SCH MED,DEPT ANAT & CELL BIOL,LOS ANGELES,CA 90024

[4] UNIV CALIF LOS ANGELES,BRAIN RES INST,LOS ANGELES,CA 90024

来源：

NEUROSCIENCE LETTERS | 1993年 / 159卷 / 1-2期

关键词：

C-FOS PROTEIN; VAGAL AFFERENT PATHWAY; NUCLEUS OF SOLITARY TRACT; ABDOMINAL SURGERY; POSTOPERATIVE ILEUS; RAT;

D O I：

10.1016/0304-3940(93)90803-S

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In a model of abdominal surgery, which consisted of cecal manipulation and induces postoperative ileus in rats, we studied c-fos protein expression in the nucleus of the solitary tract (NTS), the spinal cord and dorsal root ganglia. Abdominal surgery resulted in a significantly higher number of c-fos protein immunoreactive cells in the NTS compared with controls but not in dorsal root ganglia and resulted in only a few scattered cells in the spinal cord. Neurons expressing c-fos protein were concentrated in NTS regions where cecal afferents terminate. These findings support the hypothesis that sensory vagal pathways partly mediate abdominal surgery-induced postoperative ileus.

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页码：79 / 82

页数：4

相关论文

共 19 条

[1] REPRESENTATION OF THE CECUM IN THE LATERAL DORSAL MOTOR NUCLEUS OF THE VAGUS NERVE AND COMMISSURAL SUBNUCLEUS OF THE NUCLEUS-TRACTUS-SOLITARII IN RAT [J].

ALTSCHULER, SM ;

FERENCI, DA ;

LYNN, RB ;

MISELIS, RR .

JOURNAL OF COMPARATIVE NEUROLOGY, 1991, 304 (02) :261-274

[2] ABDOMINAL SURGERY-INDUCED DELAYED GASTRIC-EMPTYING IN RATS - ROLE OF CRF AND SENSORY NEURONS [J].

BARQUIST, E ;

ZINNER, M ;

RIVIER, J ;

TACHE, Y .

AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 262 (04) :G616-G620

[3] ELECTRICAL-STIMULATION OF VISCERAL AFFERENT PATHWAYS IN THE PELVIC NERVE INCREASES C-FOS IN THE RAT LUMBOSACRAL SPINAL-CORD [J].

BIRDER, LA ;

ROPPOLO, JR ;

IADAROLA, MJ ;

DEGROAT, WC .

NEUROSCIENCE LETTERS, 1991, 129 (02) :193-196

[4] THE EFFECT OF STIMULUS-DURATION ON NOXIOUS-STIMULUS INDUCED C-FOS EXPRESSION IN THE RODENT SPINAL-CORD [J].

BULLITT, E ;

LEE, CL ;

LIGHT, AR ;

WILLCOCKSON, H .

BRAIN RESEARCH, 1992, 580 (1-2) :172-179

[5] INDUCTION OF C-FOS-LIKE PROTEIN WITHIN THE LUMBAR SPINAL-CORD AND THALAMUS OF THE RAT FOLLOWING PERIPHERAL STIMULATION [J].

BULLITT, E .

BRAIN RESEARCH, 1989, 493 (02) :391-397

[6] REFLEX VAGAL INHIBITION OF GASTRIC-MOTILITY BY INTESTINAL NOCICEPTIVE STIMULATION IN THE CAT [J].

GLISE, H ;

ABRAHAMSSON, H .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1980, 15 (07) :769-774

[7] CALCITONIN GENE-RELATED PEPTIDE STIMULATES THE INDUCTION OF C-FOS GENE-EXPRESSION IN RAT ASTROCYTE CULTURES [J].

HAAS, CA ;

REDDINGTON, M ;

KREUTZBERG, GW .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1991, 3 (07) :708-712

[8] MORPHINE OR U-50,488 SUPPRESSES FOS PROTEIN-LIKE IMMUNOREACTIVITY IN THE SPINAL-CORD AND NUCLEUS-TRACTUS-SOLITARII EVOKED BY A NOXIOUS VISCERAL STIMULUS IN THE RAT [J].

HAMMOND, DL ;

PRESLEY, R ;

GOGAS, KR ;

BASBAUM, AI .

JOURNAL OF COMPARATIVE NEUROLOGY, 1992, 315 (02) :244-253

[9] USE OF AVIDIN-BIOTIN-PEROXIDASE COMPLEX (ABC) IN IMMUNOPEROXIDASE TECHNIQUES - A COMPARISON BETWEEN ABC AND UNLABELED ANTIBODY (PAP) PROCEDURES [J].

HSU, SM ;

RAINE, L ;

FANGER, H .

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1981, 29 (04) :577-580

[10] INDUCTION OF C-FOS-LIKE PROTEIN IN SPINAL-CORD NEURONS FOLLOWING SENSORY STIMULATION [J].

HUNT, SP ;

PINI, A ;

EVAN, G .

NATURE, 1987, 328 (6131) :632-634