CELL-PROLIFERATION IN THE RAT PITUITARY-GLAND - MECHANISM OF CONTROL IN PROLACTIN CELLS

被引：32

作者：

KALBERMANN, LE

SZIJAN, I

BURDMAN, JA

机构：

[1] Departamento de Quimica Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires

来源：

EXPERIENTIA | 1979年 / 35卷 / 05期

关键词：

D O I：

10.1007/BF01960401

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We investigated the relationship between prolactin content and DNA replication in the anterior pituitary gland. Thymidine incorporation in pregnant rats is significantly lower than in virgin controls. This is accompanied by a decreased activity of DNA polymerase. Sulpiride administration to pregnant rats enhances thymidine incorporation to levels similar to virgin controls. The results indicate a negative feedback between prolactin content and DNA synthesis in the rat anterior pituitary gland. © 1979 Birkhäuser Verlag.

引用

页码：689 / 690

页数：2

共 17 条

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