ACTION OF DECAMETHRIN (A SYNTHETIC PYRETHROID) ON THE RAT

被引:114
作者
RAY, DE
CREMER, JE
机构
[1] MRC Toxicology Unit, Medical Research Council Laboratories, Carshalton, Surrey, Woodmansterne Road
关键词
D O I
10.1016/0048-3575(79)90039-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
When administered by a variety of routes decamethrin (NRDC 161) produced a clearly defined sequence of symptoms in the rat. These involved, progressively, chewing, salivation, pawing, choreoathetosis, tonic seizures, and death. Although animals showing tonic seizures almost invariably died, the choreoathetotic symptoms were largely reversible. Animals maintained adequate blood-gas values and arterial pressure until choreoathetosis was well advanced. Electroencephalograph records showed generalized spike and wave discharges during choreoathetosis and auditory or somatosensory-evoked spike discharges prior to choreoathetosis. Symptoms were partially antagonized by atropine. It is suggested that decamethrin-induced choreoathetosis may provide a useful model for the study of related human disorders. © 1979.
引用
收藏
页码:333 / 340
页数:8
相关论文
共 7 条
[1]   TOXICITY OF NEW PYRETHROID INSECTICIDE [J].
BARNES, JM ;
VERSCHOY.RD .
NATURE, 1974, 248 (5450) :711-711
[2]   LESION OF STRIATAL NEURONS WITH KAINIC ACID PROVIDES A MODEL FOR HUNTINGTONS-CHOREA [J].
COYLE, JT ;
SCHWARCZ, R .
NATURE, 1976, 263 (5574) :244-246
[3]   SYNTHETIC INSECTICIDE WITH A NEW ORDER OF ACTIVITY [J].
ELLIOTT, M ;
FARNHAM, AW ;
JANES, NF ;
NEEDHAM, PH ;
PULMAN, DA .
NATURE, 1974, 248 (5450) :710-711
[4]  
GAWEHN K, 1974, METHOD ENZYMAT AN, V3, P1492
[5]  
RUZO LO, 1977, 174TH ACS NAT M CHIC
[6]  
Siggard-Andersen O, 1974, ACID BASE STATUS BLO, V4
[7]   RELATIONSHIP BETWEEN BRAIN LEVELS OF CISMETHRIN AND BIORESMETHRIN IN FEMALE RATS AND NEUROTOXIC EFFECTS [J].
WHITE, INH ;
VERSCHOYLE, RD ;
MORADIAN, MH ;
BARNES, JM .
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 1976, 6 (05) :491-500