EFFECTS OF NEUROTENSIN ON DOPAMINE RELEASE AND METABOLISM IN THE RAT STRIATUM AND NUCLEUS-ACCUMBENS - CROSS-VALIDATION USING INVIVO VOLTAMMETRY AND MICRODIALYSIS

被引:69
作者
BLAHA, CD [1 ]
COURY, A [1 ]
FIBIGER, HC [1 ]
PHILLIPS, AG [1 ]
机构
[1] UNIV BRITISH COLUMBIA, DEPT PSYCHOL, VANCOUVER V6T 1W5, BC, CANADA
关键词
D O I
10.1016/0306-4522(90)90176-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The effects of the neuropeptide neurotensin on dopamine release and metabolism in the posteromedial nucleus accumbens and anterior dorsomedial striatum of the anesthetized rat were investigated using in vivo chronoamperometry and intracerebral microdialysis techniques. A dose-dependent augmentation of dopamine efflux as evidenced by increases in the chronoamperometric signal was observed in the nucleus accumbens following intracerebroventricular injections of neurotensin. However, neurotensin failed to alter extracellular concentrations of dopamine in the striatum. The selective effects of neurotensin on mesolimbic dopamine neurons were confirmed using in vivo microdialysis. These results demonstrate that neurotensin can selectively enhance the release and metabolism of dopamine in neurons projecting from the ventral tegmental area to the nucleus accumbens. © 1990.
引用
收藏
页码:699 / 705
页数:7
相关论文
共 49 条