ROLE OF PERIPHERAL CATECHOLAMINES IN RESERPINE-INDUCED AMNESIA

被引：18

作者：

PALFAI, T

WALSH, TJ

机构：

[1] Psychology Research Laboratory, Syracuse University, Syracuse

来源：

BEHAVIORAL AND NEURAL BIOLOGY | 1979年 / 27卷 / 04期

关键词：

D O I：

10.1016/S0163-1047(79)91998-8

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The effect of peripherally administered catecholamines on reserpine-induced amnesia of a PA training in mice was investigated. The amnesic effect of reserpine could be blocked with 50 mg/kg DA or 0.1 or 0.75 mg/kg NE when given ip either before, immediately, or 10 min after but not 90 min following PA. Epinephrine or a lower dose of DA could not attentrate the reserpine-induced amnesia. Syrosingopine, the peripherally acting reserpine analogue also produced time-dependent retention impairments. The amnesic effects of these Rauwolfia alkaloids were interpreted in terms of their peripheral antiadrenergic actions. © 1979 Academic Press, Inc.

引用

页码：423 / 432

页数：10

共 42 条

[1] PHARMACOLOGICAL DISTINCTIONS BETWEEN ACTIVE AND PASSIVE-AVOIDANCE MEMORY FORMATION AS SHOWN BY MANIPULATION OF BIOGENIC-AMINE ACTIVE COMPOUNDS [J].