TREATMENT OF LATENT RABBIT AND HUMAN PAPILLOMAVIRUS INFECTIONS WITH 9-(2-PHOSPHONYLMETHOXY)ETHYLGUANINE (PMEG)

被引：45

作者：

KREIDER, JW

BALOGH, K

OLSON, RO

MARTIN, JC

机构：

[1] PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT MICROBIOL & IMMUNOL,HERSHEY,PA 17033

[2] BRISTOL MYERS CO,DIV PHARMACEUT RES & DEV,WALLINGFORD,CT

来源：

ANTIVIRAL RESEARCH | 1990年 / 14卷 / 01期

关键词：

Athymic mouse; Cottontail rabbit papillomavirus; Domestic rabbit; Acyclic nucleotide; Human papillomavirus type 11; PMEG;

D O I：

10.1016/0166-3542(90)90065-F

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The acyclic nucleotide PMEG was studied for effectiveness against Shope papillomavirus (CRPV) infection of rabbits and human papillomavirus type 11 (HPV-11) infections of human foreskin xenografts in athymic mice. PMEG given in the latent period strongly suppressed the subsequent growth rates of Shope papillomas. PMEG starting in the latent period and continuing for the duration of the experiment, inhibited HPV-11 infections of human skin, including condyloma growth, and synthesis of viral DNA and capsid antigen. Drug toxicity paralleled the therapeutic effects in rabbits but there was much less toxicity in athymic mice. © 1990.

引用

页码：51 / 58

页数：8

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