MANIPULATION OF BODY-FAT COMPOSITION WITH STERCULIC ACID CAN INHIBIT MAMMARY CARCINOMAS INVIVO

被引：39

作者：

KHOO, DE

FERMOR, B

MILLER, J

WOOD, CB

APOSTOLOV, K

BARKER, W

WILLIAMSON, RCN

HABIB, NA

机构：

[1] ROYAL FREE HOSP,ACAD DEPT SURG,POND ST,LONDON NW3 2QG,ENGLAND

[2] HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT SURG,LONDON W12 0HS,ENGLAND

[3] BRISTOL ROYAL INFIRM & GEN HOSP,DEPT SURG,BRISTOL BS2 8HW,AVON,ENGLAND

来源：

BRITISH JOURNAL OF CANCER | 1991年 / 63卷 / 01期

关键词：

D O I：

10.1038/bjc.1991.20

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sterculic acid, a DELTA-9-desaturase inhibitor, administered to rats caused a rise in the stearic:oleic acid ratio of total lipids in peripheral red cells, serum and liver (P < 0.001). As a reduction in the stearic:oleic acid ratio has been described in cancer cells, we investigated the effect of sterculic acid on tumour growth. Female F344 rats were injected subcutaneously with two different doses of sterculic acid for 4 weeks prior to, and 4 weeks following, implantation of a nitrosomethylurea-induced mammary tumour. Tumour growth was inhibited equally by the two doses of sterculic acid (P < 0.001). A rise in the stearic:oleic acid ratio of tumours was observed in rats treated for only 16 days with sterculic acid. Manipulation of the tissue stearic:oleic acid ratio inhibits transplanted mammary tumour growth in rats.

引用

页码：97 / 101

页数：5

共 32 条

[1] ACTIVITIES OF FATTY-ACID DESATURASES AND FATTY-ACID COMPOSITION OF LIVER-MICROSOMES IN RATS FED BETA-CAROTENE AND 13-CIS-RETINOIC ACID [J].