LINDANE-INDUCED LIVER OXIDATIVE STRESS

被引：99

作者：

VIDELA, LA

BARROS, SBM

JUNQUEIRA, VBC

机构：

[1] Unit of Biochemistry, Department of Biological Sciences, Faculty of Medicine, Santiago

[2] Department of Clinical and Toxicology Analyses, Faculty of Pharmaceutical Sciences, University of Sao Paulo, 33786 Sao Paulo, P.O. Box

[3] Department of Biochemistry, Institute of Chemistry, University of Sao Paulo, 20780 Sao Paulo, P.O. Box

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1990年 / 9卷 / 02期

基金：

巴西圣保罗研究基金会;

关键词：

Antioxidant mechanisms; Cytochrome P-450 induction; Free radical; Lindane; Lipid peroxidation; Liver injury; Oxidative stress; Superoxide radical generation;

D O I：

10.1016/0891-5849(90)90120-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The development of an oxidative stress condition in the liver by lindane intoxication is discussed as a possible hepatotoxic mechanisms of the insecticide. Lindane is metabolized by liver microsomal enzymes to a variety of metabolites, which are susceptible of conjugation for proper elimination. In addition, the interaction of lindane with the liver tissue results in teh incubation of the microsomal cytochrome P-450 system, together with enhanced rates of superoxide radical generation and a significant increase in indicators of lipid peroxidation. Concomitantly, lindane intoxidation induces a derangement of some antioxidant mechanisms of the liver cells, including decreased superoxide dismutase and catalase activities and alterations in reduced glutathione content leading to depressed GSH/GSSG ratios. The time course study of the cahnges in hepatic lipid peroxidation and antioxidant parameters are closely interrelated and conincide with the onset and progression of morphological lesions. © 1990.

引用

页码：169 / 179

页数：11

共 106 条

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