CYANIDE INTOXICATION .2. THE EFFECTS OF SYSTEMATIC CYANIDE CHALLENGE ON INDICATIVE TOXICITY PARAMETERS

被引:6
作者
BUZALEH, AM
VAZQUEZ, ES
BATLLE, AMD
机构
[1] Ctro. de Investigaciones sobre Porfirinas y Porfirias-CIPYP (CONICET, FCE y N, UBA)-Ciudad Universit
来源
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1990年 / 96卷 / 01期
关键词
D O I
10.1016/0742-8413(90)90064-G
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
1. Present studies were carried out to establish the action of cyanide maintained at a high level during a period as long as desired. 2. One of the earliest effects of cyanide seems to be the inhibition of hepatic rhodanese. These changes do not seem to occur in the blood. 3. Available cyanide labile-sulfur was always altered, unless cyanide tissue levels could not be detected. 4. The inhibitory action of cyanide on enzymatic reaction involving Schiff base intermediates was also corroborated through its effect on δ-aminolevulinate acid dehydratase activity. 5. S-Adenosyl-L-methionine was not able to modify the toxic cyanide action. © 1990.
引用
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页码:177 / 180
页数:4
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