DIETARY-LIPID MODIFICATION OF RENAL DISORDERS AND ETHER PHOSPHOLIPID-METABOLISM

被引：12

作者：

HOLUB, BJ ^{[1
]}

PHILBRICK, DJ ^{[1
]}

PARBTANI, A ^{[1
]}

CLARK, WF ^{[1
]}

机构：

[1] UNIV WESTERN ONTARIO, DEPT MED, LONDON N6A 5B7, ONTARIO, CANADA

来源：

BIOCHEMISTRY AND CELL BIOLOGY | 1991年 / 69卷 / 07期

关键词：

RENAL DISORDERS; OMEGA-3; PLATELET-ACTIVATING FACTOR; EICOSANOIDS; CYTOKINES;

D O I：

10.1139/o91-072

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The formation of arachidonic acid derived eicosanoids, including thromboxane A2 and leukotriene B4, as well as platelet-activating factor (1-O-alkyl-2-acetyl-glycerophosphocholine), has been implicated in various renal pathophysiologies. Alteration of the fatty acid composition of membrane phospholipids in platelets, the glomerulus, and inflammatory cells, and of 1-O-alkyl-2-acyl-glycerophosphocholine (platelet-activating factor precursor) can be attained by dietary lipid modifications (e.g., consumption of fish oil containing n - 3 polyunsaturated fatty acids). These changes have been associated with an attenuation in renal disease progression and modifications in the synthesis and actions-interactions of eicosanoids, cytokines, and platelet-activating factor.

引用

页码：485 / 489

页数：5

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