THE CHICKEN VASOTOCIN GENE

被引：37

作者：

HAMANN, D ^{[1
]}

HUNT, N ^{[1
]}

IVELL, R ^{[1
]}

机构：

[1] INST HORMONE & FERTIL RES, GRANDWEG 64, W-2000 HAMBURG 54, GERMANY

来源：

JOURNAL OF NEUROENDOCRINOLOGY | 1992年 / 4卷 / 04期

关键词：

VASOTOCIN; CHICKEN GENE; PROMOTER REGION; HYPOTHALAMUS;

D O I：

10.1111/j.1365-2826.1992.tb00198.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

cDNA clones corresponding to the vasotocin precursor polypeptide were isolated from a chicken hypothalamic library and sequenced. The derived amino-acid sequence indicates a precursor of comparable structural organization to that described for members of the vasotocin/vasopressin gene family from other species. Unlike in mammals the C-terminal glycopeptide moiety appears not be cleaved off from the neurophysin. Subsequent screening of a chicken genomic library permitted an analysis also of the vasotocin gene structure and exonic composition. The 5' region upstream of the first exon was sequenced and revealed an unusual pattern of 49 repetitive -YYCYCYAAAYY- motifs, together with a polyadenyl region supporting a bend in the DNA, and a long pyrimidine-rich sequence. Three AP2-like elements, identified in the mammalian vasopressin gene, were also observed in the immediate upstream region. There was no obvious homology to the promoter regions of the known oxytocin genes, nor to any other sequence deposited in available databases, nor to other known cis-elements.

引用

页码：505 / 513

页数：9

共 38 条

[1]

ACHER R, 1970, European Journal of Biochemistry, V17, P509, DOI 10.1111/j.1432-1033.1970.tb01193.x

[2] COMPARISON OF THE ESTROGEN RESPONSIVENESS OF THE RAT AND BOVINE OXYTOCIN GENE PROMOTERS [J].

ADAN, RAH ;

WALTHER, N ;

COX, JJ ;

IVELL, R ;

BURBACH, JPH .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 175 (01) :117-122

[3] OSMOTIC STIMULI AND NACL-INTAKE IN THE FOWL - RELEASE OF ARGININE VASOTOCIN AND PROLACTIN [J].

ARAD, Z ;

CHADWICK, A ;

RICE, GE ;

SKADHAUGE, E .

JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY, 1986, 156 (03) :399-406

[4] A TRANSCRIPTION FACTOR WHICH BINDS TO THE ENHANCERS OF SV40, IMMUNOGLOBULIN HEAVY-CHAIN AND U2 SNRNA GENES [J].

BOHMANN, D ;

KELLER, W ;

DALE, T ;

SCHOLER, HR ;

TEBB, G ;

MATTAJ, IW .

NATURE, 1987, 325 (6101) :268-272

[5] PRECURSORS OF MESOTOCIN AND VASOTOCIN IN BIRDS - IDENTIFICATION OF VLDV-NEUROPHYSINS AND MSEL-NEUROPHYSINS IN CHICKEN, GOOSE, AND OSTRICH [J].

CHAUVET, MT ;

LEVY, B ;

MICHEL, G ;

CHAUVET, J ;

ACHER, R .

BIOSCIENCE REPORTS, 1986, 6 (04) :381-385

[6] SUPERCOIL SEQUENCING - A FAST AND SIMPLE METHOD FOR SEQUENCING PLASMID DNA [J].

CHEN, EY ;

SEEBURG, PH .

DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY, 1985, 4 (02) :165-170

[7] CRYSTAL-STRUCTURE OF A BOVINE NEUROPHYSIN-II DIPEPTIDE COMPLEX AT 2.8-A DETERMINED FROM THE SINGLE-WAVELENGTH ANOMALOUS SCATTERING SIGNAL OF AN INCORPORATED IODINE ATOM [J].

CHEN, LQ ;

ROSE, JP ;

BRESLOW, E ;

YANG, D ;

CHANG, WR ;

FUREY, WF ;

SAX, M ;

WANG, BC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (10) :4240-4244

[8]

Davis L. G., 1986, BASIC METHODS MOL BI

[9] CHARACTERIZATION OF THE RAT PRODYNORPHIN GENE [J].

DOUGLASS, J ;

MCMURRAY, CT ;

GARRETT, JE ;

ADELMAN, JP ;

CALAVETTA, L .

MOLECULAR ENDOCRINOLOGY, 1989, 3 (12) :2070-2078

[10] COMPILATION OF VERTEBRATE-ENCODED TRANSCRIPTION FACTORS [J].

FAISST, S ;

MEYER, S .

NUCLEIC ACIDS RESEARCH, 1992, 20 (01) :3-26

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