ROLE OF MUSCLE FASCICULATIONS IN THE GENERATION OF MYOPATHIES IN MAMMALIAN SKELETAL-MUSCLE

被引：5

作者：

ADLER, M ^{[1
]}

HINMAN, D ^{[1
]}

HUDSON, CS ^{[1
]}

机构：

[1] COLORADO STATE UNIV,COLL VET MED & BIOMED SCI,DEPT ANAT & NEUROBIOL,FT COLLINS,CO 80523

来源：

BRAIN RESEARCH BULLETIN | 1992年 / 29卷 / 02期

关键词：

RAT DIAPHRAGM; NEUROMUSCULAR JUNCTION; PYRIDOSTIGMINE; CHOLINESTERASE INHIBITION; MYOPATHY; TETRODOTOXIN;

D O I：

10.1016/0361-9230(92)90024-R

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The myotoxicity of pyridostigmine bromide was investigated on rat diaphragm nerve-muscle preparations in vitro. Within 2 h of exposure to pyridostigmine (2-mu-M), diaphragm muscles exhibited ultrastructural alterations characterized by swelling of subjunctional mitochondria and disorganization of contractile proteins. These alterations developed both in the absence and presence of electrical stimulation of the phrenic nerve, and were accompanied by continuous muscle fasciculations. Pretreatment by tetrodotoxin suppressed both the muscle fasciculations and the appearance of myopathies. These findings suggest that fasciculations may be an important contributing factor in the development of anticholinesterase-induced myopathies.

引用

页码：179 / 187

页数：9

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