INTERLEUKIN-1-BETA PRODUCTION DURING THE ONSET OF HEAT-STROKE IN RABBITS

被引：77

作者：

LIN, MT

KAO, TY

SU, CF

HSU, SSF

机构：

[1] TRISERV GEN HOSP,DEPT SURG,TAIPEI,TAIWAN

[2] UNIV CALIF BERKELEY,COLL LETTERS & SCI,DEPT MOLEC & CELL BIOL,BERKELEY,CA

来源：

NEUROSCIENCE LETTERS | 1994年 / 174卷 / 01期

关键词：

HEAT STROKE; BRAIN; HYPOTHALAMUS; INTERLEUKIN-1; INTERLEUKIN-1 RECEPTOR ANTAGONIST;

D O I：

10.1016/0304-3940(94)90108-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

During the onset of heat stroke, rabbits displayed hyperthermia (42.8 degrees C), decreased arterial blood pressure, increased intracranial pressure, decreased cerebral perfusion pressure and increased interleukin-1 beta production (in both the hypothalamus and plasma), compared to those of normothermic, control rabbits. In addition, the heat-stroke animals which received an i.v. injection of interleukin 1-receptor antagonist (200 mu g/kg) had a survival time (interval between onset of heat stroke and death) longer than that of the heat-stroke animals which received control-vehicle solution. The data indicate that interleukin-1 production plays a role in pathogenesis of heat stroke in rabbits.

引用

页码：17 / 20

页数：4

共 18 条

[1] BRAIN INTERLEUKIN-1 GENE-EXPRESSION INDUCED BY PERIPHERAL LIPOPOLYSACCHARIDE ADMINISTRATION [J].