[2,3-C-13(2)]-4-HYDROXY-L-THREONINE

被引:19
作者
WOLF, E [1 ]
SPENSER, ID [1 ]
机构
[1] MCMASTER UNIV,DEPT CHEM,HAMILTON,ON L8S 4M1,CANADA
关键词
D O I
10.1021/jo00126a052
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An eight-step synthesis of{[2,3-C-13(2)]-4-hydroxy-L-threonine ([2,3-C-13(2)]-(2S,3S)-2-amino-3,4-dihydroxybutanoic acid)} is described, starting from [1,2-C-13(2)]acetylene, in an overall yield of 13%. Since a key intermediate of the synthetic sequence, 4-(benzyloxy)-(Z)-but-2-en-1-ol, is available commercially, the method furnishes a convenient four-step synthesis of nonenriched 4-hydroxy-L-threonine, in an overall yield of 27%.
引用
收藏
页码:6937 / 6940
页数:4
相关论文
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