[2,3-C-13(2)]-4-HYDROXY-L-THREONINE

An eight-step synthesis of{[2,3-C-13(2)]-4-hydroxy-L-threonine ([2,3-C-13(2)]-(2S,3S)-2-amino-3,4-dihydroxybutanoic acid)} is described, starting from [1,2-C-13(2)]acetylene, in an overall yield of 13%. Since a key intermediate of the synthetic sequence, 4-(benzyloxy)-(Z)-but-2-en-1-ol, is available commercially, the method furnishes a convenient four-step synthesis of nonenriched 4-hydroxy-L-threonine, in an overall yield of 27%.