TYPE OF STIMULATION PROTOCOL AFFECTS OOCYTE MATURITY, FERTILIZATION RATE, AND CLEAVAGE RATE AFTER INTRACYTOPLASMIC SPERM INJECTION

被引：37

作者：

GREENBLATT, EM

MERIANO, JS

CASPER, RF

机构：

[1] TORONTO CTR ADV REPROD TECHNOL, TORONTO, ON, CANADA

[2] UNIV TORONTO, TORONTO, ON M5S 1A1, CANADA

来源：

FERTILITY AND STERILITY | 1995年 / 64卷 / 03期

关键词：

GNRH-AGONISTS; STIMULATION PROTOCOLS; SHORT GNRH AGONIST PROTOCOL; LONG GNRH AGONIST PROTOCOL; OOCYTE MATURITY; INTRACYTOPLASMIC SPERM INJECTION;

D O I：

10.1016/S0015-0282(16)57792-9

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To compare oocyte maturity, fertilization rate and cleavage rate after a short and long GnRH agonist (GnRH-a) stimulation protocol and intracytoplasmic sperm injection (ICSI). Design: Retrospective study of 34 sequential ICSI cycles stimulated with a short or long GnRH-a protocol. Setting: A university-based tertiary care center for assisted reproductive treatment. Results: Significantly more oocytes were mature (metaphase II) after a long GnRH-a protocol then after a short GnRH-a protocol (25.6% and 80.8%, respectively). The long protocol resulted in more cleaving embryos (36/152 versus 9/132) and more cycles of ET (12/17 versus 5/17) than the short group. Conclusion: A greater percentage of mature oocytes results from ovarian stimulation with a long GnRH-a protocol than a short GnRH-a protocol. Maturity could be assessed accurately after cumulus stripping that is required before ICSI. Fertilization rate and cleavage rate with ICSI was superior after a long GnRH-a stimulation protocol for superovulation.

引用

页码：557 / 563

页数：7

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