LEWIS ACID-CATALYZED, HIGH-PRESSURE, STEREOSPECIFIC, REGIOSPECIFIC, DIELS-ALDER CYCLOADDITION OF UNSUBSTITUTED 2-PYRONE - SHORT SYNTHESIS OF A RACEMIC A-RING PRECURSOR TO PHYSIOLOGICALLY ACTIVE 1-HYDROXYVITAMIN D-3 STEROIDS

被引：31

作者：

POSNER, GH

ISHIHARA, Y

机构：

[1] Department of Chemistry, School of Arts, Sciences The Johns Hopkins University, Baltimore

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 41期

关键词：

D O I：

10.1016/S0040-4039(00)78339-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bicyclic lactone 1, a racemic A-ring precursor to diverse physiologically active 1-hydroxyvitamin D-3 analogs, was prepared in 91% yield via 11-12 Kbar, Lewis acid-catalyzed, 4+2-cycloaddition of unsubstituted 2-pyrone.

引用

页码：7545 / 7548

页数：4

共 39 条

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