PHARMACOLOGICALLY INTERESTING COMPOUNDS .I. HIGH RESOLUTION MASS SPECTRA OF PHENOTHIAZINES

The mass spectra of twenty‐six commercially available medicinal phenothiazines have been determined at high resolution. In each compound, the side chain attached to the 10‐position of the phenothiazine ring contains nitrogen and fission of the CC bond α to this nitrogen gives in most cases the base peak. Some of the compounds are also substituted at the 2‐position and this substituent generally remains intact, though some substituents such as acetyl, propionyl, methoxyl and methylthio can undergo fragmentation. Fragmentations fall into three groups; those which give ions representing a part of the side chain; those which give ions representing the intact phenothiazine ring with part of the side chain attached; those which give ions representing a partially fragmented ring system. Copyright © 1969 John Wiley & Sons, Ltd.