SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME ARYLHYDRAZONES OF 4-[(2-METHYLIMIDAZO[1,2-A]PYRIDINE-3-YL)AZO]BENZOIC ACID HYDRAZIDE

被引：11

作者：

CESUR, Z ^{[1
]}

BUYUKTIMKIN, S ^{[1
]}

BUYUKTIMKIN, N ^{[1
]}

DERBENTLI, S ^{[1
]}

机构：

[1] ISTANBUL UNIV,FAC MED,CTR CULTURE COLLECT,ISTANBUL,TURKEY

来源：

ARCHIV DER PHARMAZIE | 1990年 / 323卷 / 03期

关键词：

D O I：

10.1002/ardp.19903230304

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A short series of arylhydrazones of 4‐[(2‐methylimidazo[1,2‐a]pyridine‐3‐yl)azo]benzoic acid hydrazide was synthesized and tested for antimicrobial activity. All of the compounds show antimicrobial activity against Escherichia coli. A few members were also active against Klebsiella pneumoniae, Staphylococcus aureus and Pseudomonas aeruginosa. The interplanar angle (θ) between the aryl ring and the adjacent azomethine group of some representative compounds was measured by electronic absorption spectroscopy. No structure‐activity‐relationship between interplanar angle or lipophily and activity was found. Copyright © 1990 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

引用

页码：141 / 144

页数：4

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