SEPARATION OF THE ENANTIOMERIC INTERMEDIATES OF SOME PLATELET-ACTIVATING FACTOR ANALOGS ON A NAPHTHYLALANINE-TYPE PIRKLE COLUMN

被引：7

作者：

CAMACHO, PL

GEIGER, E

VIGH, G

WEBSTER, R

THOMPSON, DH

机构：

[1] OREGON GRAD INST SCI & TECHNOL,DEPT CHEM & BIOL SCI,BEAVERTON,OR 97006

[2] TEXAS A&M UNIV SYST,DEPT CHEM,COLLEGE STN,TX 77843

来源：

JOURNAL OF CHROMATOGRAPHY | 1990年 / 506卷

关键词：

D O I：

10.1016/S0021-9673(01)91609-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A chiral high-performance liquid-chromatographic separation method was developed for the analysis of some glycerol-based, ether-linked platelet-activating factor precursors. Using a d-naphthylalanine-type Pirkle-column and tetrahydrofuran-hexane eluents, the retention-structure relationships were determined for a large number of glycerol ether derivatives. The derivatives leading to the highest chiral selectivity factors in the analytical separations were surveyed for their applicability in large-scale isolation of chiral synthetic intermediates. © 1990.

引用

页码：611 / 616

页数：6

共 15 条

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