MORPHINE-INDUCED IMMUNE ALTERATIONS INVIVO

被引：63

作者：

ARORA, PK ^{[1
]}

FRIDE, E ^{[1
]}

PETITTO, J ^{[1
]}

WAGGIE, K ^{[1
]}

SKOLNICK, P ^{[1
]}

机构：

[1] NIH,DIV RES SERV,COMPARAT PATHOL SECT,BETHESDA,MD 20892

来源：

CELLULAR IMMUNOLOGY | 1990年 / 126卷 / 02期

关键词：

D O I：

10.1016/0008-8749(90)90326-M

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The high incidence of human immunodeficiency virus (HIV) seropositivity among drug abusers prompted us to examine in an animal model the effects of morphine on aspects of the immune system that may be specifically related to HIV infection. We now report a robust, sustained elevation in the ratio of CD4+/CD8+ cells in the spleen and thymus of mice chronically treated with morphine. Since CD4+ cells have been reported to be target cells for HIV, these alterations, in concert with a marked cellular atrophy that appears to be restricted to organs of the immune system, suggest that opiates may serve as cofactors in altering the immune status of the host and thus contribute to the increased susceptibility to HIV infection and eventual development of AIDS in opiate abusers. © 1990.

引用

页码：343 / 353

页数：11

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