THE INVOLVEMENT OF FATTY-ACID BINDING-PROTEIN IN PEROXISOMAL FATTY-ACID OXIDATION

被引：25

作者：

REUBSAET, FAG

VEERKAMP, JH

BRUCKWILDER, MLP

TRIJBELS, JMF

MONNENS, LAH

机构：

[1] CATHOLIC UNIV NIJMEGEN,DEPT BIOCHEM,POB 9101,6500 HB NIJMEGEN,NETHERLANDS

[2] CATHOLIC UNIV NIJMEGEN,DEPT PEDIAT,6500 HB NIJMEGEN,NETHERLANDS

来源：

FEBS LETTERS | 1990年 / 267卷 / 02期

关键词：

Acyl-CoA oxidase; Acyl-CoA translocation; Fatty acid-binding protein; Peroxisome; Rat liver; β-Oxidation;

D O I：

10.1016/0014-5793(90)80931-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rat liver fatty acid-binding protein (FABP) can function as a fatty acid donor protein for both peroxisomal and mitochondrial fatty acid oxidation, since 14C-labeled palmitic acid bound to FABP is oxidized by both organelles. FABP is, however, not detected in peroxisomes and mitochondria of rat liver by ELISA. Acyl-CoA oxidase activity of isolated peroxisomes was not changed by addition of FABP or flavaspidic acid, an inhibitor of fatty acid binding to FABP, nor by disruption of the peroxisomal membranes. These data indicate that FABP may transfer fatty acids to peroxisomes, but is not involved in the transport of acyl-CoA through the peroxisomal membrane. © 1990.

引用

页码：229 / 230

页数：2

共 18 条

[1] PARTIAL DISASSEMBLY OF PEROXISOMES [J].