CHLORAL HYDRATE OVERDOSE - TRICHLOROETHANOL DETECTION BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY

被引:8
作者
HELLER, PF
GOLDBERGER, BA
CAPLAN, YH
机构
[1] UNIV MARYLAND,SCH MED,DEPT PATHOL,111 PENN ST,BALTIMORE,MD 21201
[2] UNIV MARYLAND,SCH MED,SCH PHARM,DEPT BIOMED CHEM,BALTIMORE,MD 21201
关键词
CHLORAL HYDRATE; TRICHLOROETHANOL; FATAL INTOXICATION; GAS CHROMATOGRAPHY MASS SPECTROMETRY;
D O I
10.1016/0379-0738(92)90112-A
中图分类号
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号
0301 ; 10 ;
摘要
A case is presented where an individual ingested a fatal dose of chloral hydrate. Trichloroethanol (TCE), the metabolite of chloral hydrate, was initially identified by the Fujiwara reaction and quantified by gas chromatography/mass spectrometry in blood (127 mg/l), urine (128 mg/l) and stomach contents (25 mg total).
引用
收藏
页码:231 / 234
页数:4
相关论文
共 10 条
[1]  
BASELT RC, 1989, DISPOSITION TOXIC DR, P144
[2]   DETERMINATION OF TRICHLOROETHANOL AT THERAPEUTIC AND OVERDOSE LEVELS IN BLOOD AND URINE BY ELECTRON-CAPTURE GAS-CHROMATOGRAPHY [J].
BERRY, DJ .
JOURNAL OF CHROMATOGRAPHY, 1975, 107 (01) :107-114
[3]   GAS-CHROMATOGRAPHIC DETERMINATION OF CHLORAL HYDRATE, TRICHLOROETHANOL AND TRICHLOROACETIC-ACID IN BLOOD AND IN URINE EMPLOYING HEAD-SPACE ANALYSIS [J].
BREIMER, DD ;
KETELAARS, HC ;
VANROSSU.JM .
JOURNAL OF CHROMATOGRAPHY, 1974, 88 (01) :55-63
[4]   DETERMINATION OF CHLORAL HYDRATE TRICHLOROACETIC ACID TRICHLOROETHANOL AND UROCHLORALIC ACID IN PRESENCE OF EACH OTHER AND IN TISSUE HOMOGENATES [J].
CABANA, BE ;
GESSNER, PK .
ANALYTICAL CHEMISTRY, 1967, 39 (12) :1449-&
[5]   ANALYSIS OF CHLORMETHIAZOLE, ETHCHLORVYNOL AND TRICHLOROETHANOL IN BIOLOGICAL-FLUIDS BY GAS-LIQUID-CHROMATOGRAPHY AS AN AID TO DIAGNOSIS OF ACUTE-POISONING [J].
FLANAGAN, RJ ;
LEE, TD ;
RUTHERFORD, DM .
JOURNAL OF CHROMATOGRAPHY, 1978, 153 (02) :473-479
[6]  
JAIN N C, 1967, Journal of Forensic Sciences, V12, P497
[7]   DETERMINATION OF TRICHLOROETHYLENE METABOLITES IN RAT-LIVER HOMOGENATE USING HEADSPACE GAS-CHROMATOGRAPHY [J].
KOPPEN, B ;
DALGAARD, L ;
CHRISTENSEN, JM .
JOURNAL OF CHROMATOGRAPHY, 1988, 442 :325-332
[8]   CHLORAL HYDRATE - UNUSUALLY HIGH-CONCENTRATIONS IN A FATAL OVERDOSE [J].
LEVINE, B ;
PARK, J ;
SMITH, TD ;
CAPLAN, YH .
JOURNAL OF ANALYTICAL TOXICOLOGY, 1985, 9 (05) :232-233
[9]   SPECTROPHOTOMETRIC DETERMINATION OF TRICHLOROETHANOL IN CHLORAL HYDRATE POISONING [J].
MCBAY, AJ ;
BOLING, VR ;
REYNOLDS, PC .
JOURNAL OF ANALYTICAL TOXICOLOGY, 1980, 4 (02) :99-101
[10]   IMPROVED METHOD FOR THE ELECTRON-CAPTURE GAS-CHROMATOGRAPHIC DETERMINATION OF TRICHLOROACETIC-ACID IN HUMAN-SERUM [J].
VANDERHOEVEN, R ;
DROST, RH ;
MAES, RAA ;
DOST, F ;
PLOMP, TA ;
PLOMP, GJJ .
JOURNAL OF CHROMATOGRAPHY, 1979, 164 (01) :106-108