RATES OF GERM TUBE FORMATION FROM GROWING AND NONGROWING YEAST-CELLS OF CANDIDA-ALBICANS

被引:5
作者
BUCHAN, ADB
GOW, NAR
机构
[1] MIT, DEPT BIOL, 77 MASSACHUSETTS AVE, CAMBRIDGE, MA 02139 USA
[2] UNIV ABERDEEN MARISCHAL COLL, DEPT MOLEC & CELL BIOL, ABERDEEN AB9 1AS, SCOTLAND
关键词
DIMORPHISM; CANDIDA-ALBICANS; DIFFERENTIATION;
D O I
10.1016/0378-1097(91)90463-K
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The rates of germ tube formation from growing and non-growing yeast cells of Candida albicans were investigated using a protocol for dimorphism regulated by temperature and pH. Stationary-phase cells formed germ tubes less rapidly than yeast cells that were preincubated in fresh growth medium prior to induction of dimorphism by an upshift in temperature or pH. On the basis of experiments using inhibitors of macromolecular biosyntheses it is suggested that the accelerated growth kinetics required de novo RNA and protein biosynthesis, but not DNA synthesis. The results suggest that metabolically active yeast cells are better able to undergo dimorphism than non-growing cells.
引用
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页码:15 / 18
页数:4
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