RELATIONSHIP BETWEEN LEVODOPA-INDEPENDENT SYMPTOMS AND CENTRAL ATROPHY EVALUATED BY MAGNETIC-RESONANCE-IMAGING IN PARKINSONS-DISEASE

被引：14

作者：

DURIF, F ^{[1
]}

POLLAK, P ^{[1
]}

HOMMEL, M ^{[1
]}

ARDOUIN, C ^{[1
]}

LEBAS, JF ^{[1
]}

CROUZET, G ^{[1
]}

PERRET, J ^{[1
]}

机构：

[1] CHR UNIV GRENOBLE,DEPT NEUROSCI CLIN & BIOL,GRENOBLE,FRANCE

来源：

EUROPEAN NEUROLOGY | 1992年 / 32卷 / 01期

关键词：

BASAL GANGLIA DISEASES; PARKINSONS DISEASE; MAGNETIC RESONANCE IMAGING;

D O I：

10.1159/000116784

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Thirty patients with Parkinson's disease were studied for the purpose of investigation relations between motor symptoms and cerebral atrophy evaluated by magnetic resonance imaging (MRI). Axial symptoms (gait disorder, postural instability and difficulty in arising from a chair), assessed at the time of maximum clinical improvement, were significantly correlated with frontal atrophy, while no correlation was found between the basal parkinsonian disability score and cerebral atrophy. It is suggested that frontal atrophy observed by MRI is linked with axial motor symptoms resulting from non-dopaminergic lesions. The origin of this atrophy is unknown.

引用

页码：32 / 36

页数：5

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