THE EFFECT OF VITAMIN-D ON RAT INTESTINAL PLASMA-MEMBRANE CA-PUMP MESSENGER-RNA

被引：49

作者：

ZELINSKI, JM

SYKES, DE

WEISER, MM

机构：

[1] BUFFALO GEN HOSP,E-3,100 HIGH ST,BUFFALO,NY 14203

[2] SUNY BUFFALO,DEPT MED,DIV GASTROENTEROL,BUFFALO,NY 14260

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 179卷 / 02期

关键词：

D O I：

10.1016/0006-291X(91)91880-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of vitamin D on steady-state levels of rat intestinal Ca-pump mRNA were examined in RNA extracted from isolated cell fractions of the crypt-to-villus gradient of differentiation. Northern blots revealed three different size mRNAs. Vitamin D deficient animals showed a decrease in these Ca-pump mRNAs, which increased markedly after 1,25-(OH)2D3 repletion, particularly for the villus cell. The data suggest that one of the effects of 1,25-(OH)2D3 may be to modulate enterocyte Ca-pump mRNA and that this effect is partly dependent on the stage of cell differentiation. © 1991.

引用

页码：749 / 755

页数：7

共 21 条

[1] KINETICS OF SUB-CELLULAR DISTRIBUTION IN RAT INTESTINE OF 1,25-DIHYDROXYCHOLECALCIFEROL ADMINISTERED INVIVO - EVIDENCE FOR CONCENTRATION WITHIN 5 MIN INTO PURIFIED NUCLEI [J].