EXTRACELLULAR ALKALINE SHIFTS IN RAT HIPPOCAMPAL SLICE ARE MEDIATED BY NMDA AND NON-NMDA RECEPTORS

被引:41
作者
CHEN, JCT
CHESLER, M
机构
[1] NYU MED CTR,DEPT PHYSIOL & BIOPHYS,550 IST AVE,NEW YORK,NY 10016
[2] NYU MED CTR,DEPT NEUROSURG,NEW YORK,NY 10016
关键词
D O I
10.1152/jn.1992.68.1.342
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
1. The pharmacology of synaptically evoked extracellular alkaline shifts was studied in the CA1 area of rat hippocampal slices. 2. Stimulus-evoked alkalinizations were unaffected by 2-amino-5-phosphonovalerate (APV) (20-mu-M). 3. 6-Cyano-7-nitro-nitroquinoxaline-2,3-dione (CNQX) (10-mu-M) inhibited the alkalinizations. In the continued presence of CNQX, an APV-sensitive, picrotoxin-insensitive, alkaline shift was elicited in low Mg2+ media. 4. Antidromic stimulation produced small alkaline shifts in comparison with orthodromic activation. 5. Our results demonstrate that in the hippocampal CA1 region, synaptically evoked alkalinizations can arise through both N-methyl-D-aspartate (NMDA) and non-NMDA glutamate receptors. These responses cannot be explained by cell firing per se.
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页码:342 / 344
页数:3
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