ENHANCED DEGRADATION OF THE FERRITIN REPRESSOR PROTEIN DURING INDUCTION OF FERRITIN MESSENGER-RNA TRANSLATION

被引：46

作者：

GOESSLING, LS ^{[1
]}

DANIELSMCQUEEN, S ^{[1
]}

BHATTACHARYYAPAKRASI, M ^{[1
]}

LIN, JJ ^{[1
]}

THACH, RE ^{[1
]}

机构：

[1] WASHINGTON UNIV,DEPT BIOL,ST LOUIS,MO 63130

来源：

SCIENCE | 1992年 / 256卷 / 5057期

关键词：

D O I：

10.1126/science.1316633

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Induction of ferritin synthesis in cultured cells by heme or iron is accompanied by degradation of the ferritin repressor protein (FRP). Intermediates in the degradative pathway apparently include FRP covalently linked in larger aggregates. The effect of iron on FRP degradation is enhanced by porphyrin precursors but is decreased by inhibitors of porphyrin synthesis, which implies that heme is an active agent. These results suggest that translational induction in this system may be caused by enhanced repressor degradation. While unique among translational regulatory systems, this process is common to a variety of other biosynthetic control mechanisms.

引用

页码：670 / 673

页数：4

共 42 条

[1] THE EFFECTS OF INHIBITION OF HEME-SYNTHESIS ON THE INTRACELLULAR-LOCALIZATION OF IRON IN RAT RETICULOCYTES [J].