INCREASED INTERLEUKIN-6, BUT REDUCED INTERLEUKIN-1, IN DELAYED PRESSURE URTICARIA

被引:41
作者
LAWLOR, F [1 ]
BIRD, C [1 ]
CAMP, RDR [1 ]
BARLOW, R [1 ]
BARR, RM [1 ]
KOBZABLACK, A [1 ]
JUDGE, MR [1 ]
GREAVES, MW [1 ]
机构
[1] NATL INST BIOL STAND & CONTROLS, S MIMMS, HERTS, ENGLAND
关键词
D O I
10.1111/j.1365-2133.1993.tb00225.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Interleukin 1 (IL-1) and interleukin 6 (IL-6) were measured by bioassays in suction-blister exudates from lesional skin, from skin immediately following a pressure challenge, and from control skin (not subjected to pressure) of patients with delayed pressure urticaria. IL-6 activity in lesional exudates was significantly higher than in exudates from the other two sites. IL- 1 activity in lesional exudates was not significantly higher than in the control exudates, but significantly less IL-1 activity was found immediately after pressure challenge than from the control site.
引用
收藏
页码:500 / 503
页数:4
相关论文
共 25 条
[1]  
BACON K, 1990, Cytokine, V2, P100, DOI 10.1016/1043-4666(90)90003-C
[2]   POTENT AND SPECIFIC-INHIBITION OF IL-8-INDUCED, IL-1-ALPHA-INDUCED AND IL-1-BETA-INDUCED INVITRO HUMAN LYMPHOCYTE MIGRATION BY CALCIUM-CHANNEL ANTAGONISTS [J].
BACON, KB ;
WESTWICK, J ;
CAMP, RDR .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 165 (01) :349-354
[3]   POTENT INFLAMMATORY PROPERTIES IN HUMAN SKIN OF INTERLEUKIN-1 ALPHA-LIKE MATERIAL ISOLATED FROM NORMAL SKIN [J].
CAMP, R ;
FINCHAM, N ;
ROSS, J ;
BIRD, C ;
GEARING, A .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1990, 94 (06) :735-741
[4]  
CAMP R, 1992, J INVEST DERMATOL, V98, P536
[5]   PROTEASE INHIBITORS IN PLASMA OF PATIENTS WITH CHRONIC URTICARIA [J].
DOEGLAS, HMG ;
BLEUMINK, E .
ARCHIVES OF DERMATOLOGY, 1975, 111 (08) :979-985
[6]   DELAYED PRESSURE URTICARIA - CLINICAL-FEATURES, LABORATORY INVESTIGATIONS, AND RESPONSE TO THERAPY OF 44 PATIENTS [J].
DOVER, JS ;
BLACK, AK ;
WARD, AM ;
GREAVES, MW .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1988, 18 (06) :1289-1298
[7]   PRESENCE OF EPIDERMAL-DERIVED THYMOCYTE ACTIVATING FACTOR INTERLEUKIN-1 IN NORMAL HUMAN STRATUM-CORNEUM [J].
GAHRING, LC ;
BUCKLEY, A ;
DAYNES, RA .
JOURNAL OF CLINICAL INVESTIGATION, 1985, 76 (04) :1585-1591
[8]   A SIMPLE SENSITIVE BIOASSAY FOR INTERLEUKIN-1 WHICH IS UNRESPONSIVE TO 10(3) U/ML OF INTERLEUKIN-2 [J].
GEARING, AJH ;
BIRD, CR ;
BRISTOW, A ;
POOLE, S ;
THORPE, R .
JOURNAL OF IMMUNOLOGICAL METHODS, 1987, 99 (01) :7-11
[9]   INTERLEUKIN-6 IS EXPRESSED IN HIGH-LEVELS IN PSORIATIC SKIN AND STIMULATES PROLIFERATION OF CULTURED HUMAN KERATINOCYTES [J].
GROSSMAN, RM ;
KRUEGER, J ;
YOURISH, D ;
GRANELLIPIPERNO, A ;
MURPHY, DP ;
MAY, LT ;
KUPPER, TS ;
SEHGAL, PB ;
GOTTLIEB, AB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (16) :6367-6371
[10]  
HAUSER C, 1986, J IMMUNOL, V136, P3317