THE MAXIMUM RATE OF NEUROFILAMENT TRANSPORT IN AXONS - A VIEW OF MOLECULAR-TRANSPORT MECHANISMS CONTINUOUSLY ENGAGED

被引：43

作者：

LASEK, RJ ^{[1
]}

PAGGI, P ^{[1
]}

KATZ, MJ ^{[1
]}

机构：

[1] UNIV ROMA LA SAPIENZA, DIPARTIMENTO BIOL CELLULARE & SVILUPPO, I-00185 ROME, ITALY

来源：

BRAIN RESEARCH | 1993年 / 616卷 / 1-2期

关键词：

AXONAL TRANSPORT; CELL MOTILITY; CYTOSKELETON; NEUROFILAMENT; POLYMER;

D O I：

10.1016/0006-8993(93)90192-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neurofilaments (NFs) were radiolabeled in the optic systems of mice. The leading edge of the radiolabeled NF waveform was distinguished near the injection site (the eye) both by liquid scintillation spectroscopy and visually from fluorographs. The fastest NFs were found to be translocated at rates of between 72 and 144 mm/day. It appears that the continuous (maximal) operation of the slow axonal transport machinery can move polymers intra-axonally at rates one hundred times greater than those previously reported.

引用

页码：58 / 64

页数：7

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