ENDOTHELIN AND MYOCARDIAL-ISCHEMIA

被引：50

作者：

HASDAI, D ^{[1
]}

KORNOWSKI, R ^{[1
]}

BATTLER, A ^{[1
]}

机构：

[1] TEL AVIV UNIV,SACKLER FAC MED,NEUFELD CARDIAC RES INST,IL-69978 TEL AVIV,ISRAEL

来源：

CARDIOVASCULAR DRUGS AND THERAPY | 1994年 / 8卷 / 04期

关键词：

ENDOTHELIN; MYOCARDIAL ISCHEMIA; MYOCARDIAL INFARCTION; REPERFUSION; ANGINA PECTORIS; HEART;

D O I：

10.1007/BF00877413

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Endothelin is a potent vasoconstrictor with a wide range of effects on the heart. Changes in myocardial and circulating levels of endothelin have been described in various experimental models of myocardial ischemia, and in humans with acute myocardial infarction and different forms of angina pectoris. The role played by endothelin in the different states of myocardial ischemia is unclear. However, myocardial damage has been shown to be reduced in several experimental models of myocardial infarction by administering agents that block the action of endothelin. The aim of this review article is to present the current literature concerning the interaction between endothelin and the various forms of myocardial ischemia, and to explore the significance of such interactions.

引用

页码：589 / 599

页数：11

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