RESPONSE OF PONIES TO ADJUVANTED EHV-1 WHOLE VIRUS-VACCINE AND CHALLENGE WITH VIRUS OF THE HOMOLOGOUS STRAIN

被引：19

作者：

DOLBY, CA ^{[1
]}

HANNANT, D ^{[1
]}

MUMFORD, JA ^{[1
]}

机构：

[1] ANIM HLTH TRUST,DEPT INFECT DIS,POB 5,NEWMARKET CB8 7DW,SUFFOLK,ENGLAND

来源：

BRITISH VETERINARY JOURNAL | 1995年 / 151卷 / 01期

关键词：

EQUID HERPESVIRUS TYPE-1 (EHV-1); ADJUVANTS; SEROLOGICAL RESPONSES; CHALLENGE INFECTION;

D O I：

10.1016/S0007-1935(05)80061-2

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Five yearling ponies were vaccinated with inactivated Equid herpesvirus type 1 (EHV-1) in Freund's complete adjuvant as a double emulsion and revaccinated 6 weeks later with EHV-1 in Freund's incomplete adjuvant. These ponies and three age-matched controls were challenged intra-nasally after a further 6 weeks with homologuous live virus and monitored clinically, biologically and serologically. After challenge, clinical signs were mild in both groups. No cell-associated viraemias were detected in vaccinated ponies. Vaccination induced high levels of complement-fixing (CF) and virus-neutralizing (VN) antibody, and elicited a response to all major viral glycoproteins as shown by western blot analysis.

引用

页码：27 / 37

页数：11

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