REGULATION OF CYCLIC-AMP PRODUCTION IN ADULT HUMAN CILIARY PROCESSES

被引:17
作者
BAUSHER, LP
HORIO, B
机构
[1] Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT
关键词
CILIARY PROCESSES; CYCLIC AMP; VIP; BETA-ADRENERGIC RECEPTOR; ALPHA(2)-ADRENERGIC RECEPTOR; ENDOTHELIN;
D O I
10.1016/S0014-4835(05)80082-X
中图分类号
R77 [眼科学];
学科分类号
100212 [眼科学];
摘要
Cyclic AMP production in intact ciliary processes from elderly human donors is subject to stimulatory and inhibitory control by various agents. Stimulation of cAMP production is observed with forskolin, vasoactive intestinal peptide, or the beta-adrenergic agonist isoproterenol. Inhibition of forskolin-stimulated cAMP production is observed with endothelin-2 or PAC. The inhibitory effect of PAC is blocked by the specific alpha(2)-adrenergic antagonist, yohimbine. Endothelin-2 has no effect on basal cAMP production. These data document the positive and negative regulation of cAMP responses in adult human ciliary processes and support the idea that cAMP is a key intermediate in the regulation of aqueous humor formation.
引用
收藏
页码:43 / 48
页数:6
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