AMPLIFICATION OF RESPONSES TO SUMATRIPTAN BY VARIOUS AGONISTS IN RABBIT ISOLATED ILIAC ARTERY

被引：27

作者：

YILDIZ, O

TUNCER, M

机构：

[1] HACETTEPE UNIV,FAC MED,DEPT PHARMACOL,ANKARA 06100,TURKEY

[2] GULHANE MIL MED ACAD,FAC MED,DEPT PHARMACOL,ANKARA,TURKEY

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 1995年 / 25卷 / 03期

关键词：

VASCULAR; 5-HT1; LIKE RECEPTORS; SUMATRIPTAN; AMPLIFICATION; PRECONTRACTION; RABBIT ILIAC ARTERY;

D O I：

10.1097/00005344-199503000-00025

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rabbit iliac arteries (IA) were almost unresponsive to the serotonin (5-HT1-like) receptor agonist sumatriptan under control conditions, whereas this agent elicited concentration-dependent contractions in IA rings given a moderate tone by threshold concentrations (EC(10)-EC(20)) of prostaglandin F-2 alpha(PGF(2 alpha)), angiotensin II (AII), histamine, norepinephrine (NE), phenylephrine (PE), or potassium chloride. These results suggest that 5-HT1-like receptors are uncovered not only by histamine or thromboxane/prostaglandin receptor agonists, as shown in rabbit renal and femoral arteries, but also by various agonists in rabbit IA as shown in this study.

引用

页码：508 / 510

页数：3

共 17 条

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