EXPRESSION OF RETINOBLASTOMA GENE (RB) PROTEIN IN T12MO PROSTATIC ADENOCARCINOMA

被引：13

作者：

VESALAINEN, S

LIPPONEN, P

机构：

[1] UNIV KUOPIO,DEPT PATHOL & FORENS MED,SF-70211 KUOPIO,FINLAND

[2] UNIV KUOPIO,DEPT SURG,SF-70211 KUOPIO,FINLAND

来源：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 1995年 / 121卷 / 07期

关键词：

PROSTATIC ADENOCARCINOMA; RB PROTEIN; PROGRESSION; SURVIVAL;

D O I：

10.1007/BF01212951

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The expression of Rb protein was analysed by immunocytochemical methods in 118 patients with T12MO prostatic adenocarcinoma who were followed-up for more than 12 years. Rb protein was expressed in 117/118 (99%) tumours. The fraction of positive nuclei was (mean +/- SD, 92 +/- 19%) and only one tumour was completely negative for Rb protein. Abnormal expression of the Rb protein (in fewer than 90% of cells) was independent of the T category while there was a significant relationship between DNA ploidy (P = 0.0138), S-phase fraction (P = 0.0042) and expression of the Rb protein. Abnormal expression of the Rb protein had no prognostic value while T category (P = 0.0017), Gleason score (P = 0.0097), DNA ploidy (P = 0.0034), S-phase fraction (P = 0.0179) and mitotic index (P = 0.0001) were significant prognostic factors. In multivariate analysis the only independent predictor was the mitotic index [Risk ratio (RR) (95%CI)= 7.4(2.4-22.5), P = 0.004]. The results show that Rb protein immunohistochemistry has hardly any prognostic significance in prostatic adenocarcinoma whereas direct measurement of cell proliferative activity contains significant prognostic information.

引用

页码：429 / 433

页数：5

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