LAMOTRIGINE PROTECTS AGAINST KAINATE BUT NOT IBOTENATE LESIONS IN RAT STRIATUM

被引：67

作者：

MCGEER, EG

ZHU, SG

机构：

[1] Kinsmen Laboratory of Neurological Research, Department of Psychiatry, University of British Columbia, Vancouver, BC

来源：

NEUROSCIENCE LETTERS | 1990年 / 112卷 / 2-3期

基金：

英国医学研究理事会;

关键词：

Choline acetyltransferase; Glutamate decarboxylase; Glutamate release; Huntington's disease; Ibotenic acid; Kainic acid; Quinolinic acid;

D O I：

10.1016/0304-3940(90)90229-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pretreatment of rats with 8-16 mg/kg of lamotrigine 1 h before intrastriatal injections of 2 nm of kainic acid significantly attenuated the neurotoxicity as evidenced by measurements of striatal choline acetyltransferase and glutamate decarboxylase activities. No significant effect was seen on the toxicity of intrastriatal injections of quinolinic acid or ibotenic acid. These differential effects are further evidence that these neurotoxins act at different excitatory amino acid receptors and that the neurotoxicity of kainate is uniquely dependent on neuronally released glutamate. © 1990.

引用

页码：348 / 351

页数：4

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