METABOLISM AND DISPOSITION OF 3-METHYLINDOLE IN GOATS

被引：43

作者：

HAMMOND, AC ^{[1
]}

CARLSON, JR ^{[1
]}

WILLETT, JD ^{[1
]}

机构：

[1] UNIV IDAHO,DEPT CHEM,MOSCOW,ID 83843

来源：

LIFE SCIENCES | 1979年 / 25卷 / 15期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0024-3205(79)90395-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The metabolism and disposition of 3-methylindole (3MI), a ruminal metabolite of L-tryptophan which causes acute pulmonary edema and emphysema (APE) when administered to cattle, goats, and sheep was investigated. Goats given jugular infusions of [14C] 3MI excreted 87 to 92% of the infused radioactivity in the urine, 0.4 to 0.9% in expired air, and negligible amounts in the feces over a period of three days. Composite urine samples were fractionated into 10 peaks by ion exchange chromatography, which represented 80% of the urinary radioactivity. A major route of metabolism involved formation of 3-methyloxindole and suggests that a mixed function oxidase (MFO), pyrrolooxygenase, may be the major metabolic system involved. A minor route of metabolism involved oxidation of the methyl carbon of 3MI. © 1979.

引用

页码：1301 / 1306

页数：6

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