INHIBITION OF EGF-INDUCED PHOSPHOLIPASE-C ACTIVATION IN A431 CELLS BY ERBSTATIN, A TYROSINE KINASE INHIBITOR

被引：17

作者：

IMOTO, M

SHIMURA, N

UI, H

UMEZAWA, K

机构：

[1] Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 223, 3-14-1 Hiyoshi, Kohoku-ku, Yakohama

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 173卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(05)81042-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Erbstatin, a tyrosine kinase inhibitor, inhibited epidermal growth factor (EGF)-induced inositol phosphate production in cultured A431 cells. However, it did not inhibit ATP-induced inositol phosphate production. Cytosolic but not membrane-associated phospholipase C was iactivated by EGF, and erbstatin inhibited enhancement of the phospholipiase C activity in EGF-treated cells. Thus, tyrosine kinase of A431 cells is suggested to be functionally involved in phospholipase C activation. © 1990 Academic Press, Inc.

引用

页码：208 / 211

页数：4

共 14 条

[1] INOSITOL TRISPHOSPHATE FORMATION AND CALCIUM MOBILIZATION IN SWISS 3T3 CELLS IN RESPONSE TO PLATELET-DERIVED GROWTH-FACTOR [J].