PROGNOSTIC-SIGNIFICANCE OF THE EVALUATION OF BRONCHOALVEOLAR LAVAGE CELL-POPULATIONS IN PATIENTS WITH HIV-1 INFECTION AND PULMONARY INVOLVEMENT

被引：32

作者：

AGOSTINI, C

ZAMBELLO, R

TRENTIN, L

POLETTI, V

SPIGA, L

GRITTI, F

CIPRIANI, A

SALMASO, L

CADROBBI, P

SEMENZATO, G

机构：

[1] PADUA HOSP,DEPT PNEUMOL,PADUA,ITALY

[2] PADUA HOSP,DEPT INFECT DIS,PADUA,ITALY

[3] BELLARIA HOSP,DEPT PNEUMOL,BOLOGNA,ITALY

[4] MAGGIORE HOSP,DEPT INFECT DIS,BOLOGNA,ITALY

[5] UNIV PADUA,SCH MED,DEPT CLIN MED,I-35100 PADUA,ITALY

[6] UNIV PADUA,SCH MED,MED CLIN 1,I-35100 PADUA,ITALY

[7] UNIV PADUA,SCH MED,CLIN IMMUNOL BRANCH,I-35100 PADUA,ITALY

来源：

CHEST | 1991年 / 100卷 / 06期

关键词：

D O I：

10.1378/chest.100.6.1601

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

To investigate the prognostic utility of the morphologic and immunologic evaluation of BAL cell populations in determining mortality risk, we analyzed BAL data obtained from 115 patients infected with HIV-1. Forty fatal outcomes occurred within 73 patients with OI. The OI patients who died showed a significant increase in neutrophils with respect to surviving patients. Furthermore, the finding of a BAL neutrophilia in HIV-1-infected patients with 01 strongly correlated with a high risk of death. Among 42 cases without OI, 11 patients died. Patients without OI who had a fatal outcome showed an increase in CD3+ and CD8+ BAL lymphocytes with respect to the survivors. The presence of a lymphocytic alveolitis was associated with a significant increase in the mortality rate. Taken together our data suggest that the evaluation of the BAL cell populations might be useful in predicting the risk of fatal outcome in patients with HIV-1 infection.

引用

页码：1601 / 1606

页数：6

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