RELATIVE ROLE OF BONE AND KIDNEY IN THE HYPERCALCEMIA ASSOCIATED WITH THE RAT WALKER CARCINOSARCOMA-256

被引：4

作者：

HURTADO, J

ESBRIT, P

RAPADO, A

机构：

[1] Laboratorio de la Unidad Metabólica, Fundación Jiménez Diaz-C.S.I.C., 28040 Madrid

来源：

EUROPEAN JOURNAL OF CANCER | 1991年 / 27卷 / 01期

关键词：

D O I：

10.1016/0277-5379(91)90066-M

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The rat Walker carcinosarcoma 256 is an animal model for humoral hypercalcaemia of malignancy (HHM). In this model, the relative contribution of bone and kidney in the hypercalcaemia of tumor-bearing rats was investigated. Daily administration of pamidronate, a bone resorption inhibitor, for 2 days prevented the increased fasting Ca2+ excretion observed in the hypercalcaemic rats, although serum Ca2+ remained high. However, the high serum Ca2+ normalised after the acute injection of ethiofos, an inhibitor of renal Ca2+ reabsorption, which was associated with a marked increase of Ca2+ excretion. Changes in Ca2+ were accompanied by similar changes in Mg2+. The results indicate that altered renal Ca2+ handling has a key role in the hypercalcaemia associated with this HHM model.

引用

页码：76 / 79

页数：4

共 22 条

[1] BONE AND PARATHYROID INHIBITORY EFFECTS OF S-2(3-AMINOPROPYLAMINO)ETHYLPHOSPHOROTHIOIC ACID - STUDIES IN EXPERIMENTAL-ANIMALS AND CULTURED BONE-CELLS [J].