ALTERATION OF 2ND MESSENGER SYSTEMS AFTER TRANSIENT CEREBRAL-ISCHEMIA IN GERBILS - PROTECTIVE EFFECT OF PENTOBARBITAL AND AN AUTORADIOGRAPHIC ANALYSIS

被引：17

作者：

ARAKI, T ^{[1
]}

KATO, H ^{[1
]}

KOGURE, K ^{[1
]}

机构：

[1] TOHOKU UNIV,SCH MED,INST BRAIN RES,DEPT NEUROL,SENDAI,MIYAGI 980,JAPAN

来源：

NEUROSCIENCE LETTERS | 1991年 / 130卷 / 01期

关键词：

PROTEIN KINASE-C; INOSITOL-1,4,5-TRISPHOSPHATE; AUTORADIOGRAPHY; CEREBRAL ISCHEMIA; PENTOBARBITAL; GERBIL; SELECTIVELY VULNERABLE AREA;

D O I：

10.1016/0304-3940(91)90226-J

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The postischemic alteration of second messenger systems in the gerbil brain was analyzed by receptor autoradiography using [H-3]phorbol 12,13-dibutyrate (PDBu) and [H-3]inositol 1,4,5-trisphosphate (IP3). The alteration of the [H-3]PDBu binding in striatum and hippocampus was milder than that of the [H-3]IP3 binding 5 h and 7 days after 10-min ischemia. The administration of pentobarbital prevented a decrease in the [H-3]IP3 binding sites in all areas 5 h and 7 days after ischemia. These results suggest that the disruption of intracellular calcium homeostatis may play an important factor in ischemic brain damage.

引用

页码：57 / 60

页数：4

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