ESTRADIOLS MODIFIED BY METAL-CARBONYL CLUSTERS AS SUICIDE SUBSTRATES FOR THE STUDY OF RECEPTOR PROTEINS - APPLICATION TO THE ESTRADIOL-RECEPTOR

被引：47

作者：

VESSIERES, A

TOP, S

VAILLANT, C

OSELLA, D

MORNON, JP

JAOUEN, G

机构：

[1] ECOLE NATL SUPER CHIM,CNRS,URA 403,11 RUE P & M CURIE,F-75231 PARIS 05,FRANCE

[2] DIPARTIMENTO CHIM INORGAN,TURIN,ITALY

[3] UNIV PARIS 06,F-75230 PARIS 05,FRANCE

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1992年 / 31卷 / 06期

关键词：

D O I：

10.1002/anie.199207531

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Derivatizing biomolecules with transition-metal fragments can be a useful approach to some biochemical problems, for example in labeling hormone receptors. The estradiol derivatives 1-4 deactivate the estradiol receptor to varying degrees, allowing conclusions to be drawn concerning the chemical environment of the binding site.

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页码：753 / 755

页数：3

相关论文

共 29 条

[1] SYNTHESIS AND REACTIVITY OF TRINUCLEAR OSMIUM AND DINUCLEAR AND TRINUCLEAR RUTHENIUM COMPOUNDS DERIVED FROM HYDROXYALKYNES [J].

AIME, S ;

DEEMING, AJ .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1981, (03) :828-832

[2]

ALLEE BL, 1991, PERSPECTIVES BIOCH, P69

[3] SULFHYDRYL-MODIFYING REAGENTS REVERSIBLY INHIBIT BINDING OF GLUCOCORTICOID RECEPTOR COMPLEXES TO DNA-CELLULOSE [J].

BODWELL, JE ;

HOLBROOK, NJ ;

MUNCK, A .

BIOCHEMISTRY, 1984, 23 (07) :1392-1398

[4] REACTIONS OF FERROCENYL-STABILIZED CARBOCATIONS WITH WATER - SUBSTITUENT, MEDIUM, SALT, AND SOLVENT ISOTOPE EFFECTS ON RATES AND EQUILIBRIA [J].

BUNTON, CA ;

CARRASCO, N ;

WATTS, WE .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1979, (09) :1267-1273

[5] CARBONIUM IONS .1. AN ACIDITY FUNCTION (CO) DERIVED FROM ARYLCARBONIUM ION EQUILIBRIA [J].

DENO, NC ;

JARUZELSKI, JJ ;

SCHRIESHEIM, A .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1955, 77 (11) :3044-3051

[6] SYNTHESIS, REACTIVITY AND STRUCTURE OF FUNCTIONALLY SUBSTITUTED TRIMETALLIC CLUSTERS OF RUTHENIUM [J].

ERMER, S ;

KARPELUS, R ;

MIURA, S ;

ROSENBERG, E ;

TIRIPICCHIO, A ;

MANOTTILANFREDI, AM .

JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1980, 187 (01) :81-90

[7] A PROPOSED CONSENSUS STEROID-BINDING SEQUENCE - A REPLY [J].

FAWELL, SE ;

LEES, JA ;

PARKER, MG .

MOLECULAR ENDOCRINOLOGY, 1989, 3 (06) :1002-1005

[8] CHARACTERIZATION AND COLOCALIZATION OF STEROID BINDING AND DIMERIZATION ACTIVITIES IN THE MOUSE ESTROGEN-RECEPTOR [J].

FAWELL, SE ;

LEES, JA ;

WHITE, R ;

PARKER, MG .

CELL, 1990, 60 (06) :953-962

[9] HUMAN ESTROGEN-RECEPTOR CDNA - SEQUENCE, EXPRESSION AND HOMOLOGY TO V-ERB-A [J].

GREEN, S ;

WALTER, P ;

KUMAR, V ;

KRUST, A ;

BORNERT, JM ;

ARGOS, P ;

CHAMBON, P .

NATURE, 1986, 320 (6058) :134-139

[10] ELECTRONIC AND STERIC FACTORS FOR ELIMINATION-REACTIONS IN CARBENIUM IONS DERIVED FROM (17-BETA-ETHYNYLESTRADIOL)M2L6 COMPLEXES (M2L6 = CO2(CO)6, MO2CP2(CO)4) - X-RAY STRUCTURE OF [MO2CP2(CO)4(MU-CH=CC19H25O)]+BF4- [J].

GRUSELLE, M ;

CORDIER, C ;

SALMAIN, M ;

AMOURI, H ;

GUERIN, C ;

VAISSERMANN, J ;

JAOUEN, G .

ORGANOMETALLICS, 1990, 9 (11) :2993-2997