Garlic and its Organosulfides as Potential Chemopreventive Agents: A Review

被引:9
作者
Arora, Annu [1 ]
Tripathi, Chitra [1 ]
Shukla, Yogeshwer [1 ]
机构
[1] Ind Toxicol Res Ctr, Environm Carcinogenesis Div, POB 80,MG Marg, Lucknow 226001, Uttar Pradesh, India
关键词
Garlic; Organosulfur compounds; Cancer; Antioxidative; Antimutagenic; Antitumorigenic;
D O I
10.2174/1573394054021772
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
There are many biological plausible reasons, which showed that plant food could prevent/delay the appearance of many diseases including cancer. Garlic has been reported to possess therapeutic properties from centuries and is probably the most widely studied medicinal plant. Garlic contains a number of organosulfur compounds such as SAC, S-allyl mercaptocysteine, allicin, ajoene, DAS and other structurally related compounds, which are widely believed to be active agents in preventing cancer. Epidemiological as well as experimental studies have provided sufficient evidences that garlic along with its organosulfur components possess pleiotropic beneficial health effects including antioxidative, antimutagenic and anti-tumorigenic properties.
引用
收藏
页码:199 / 205
页数:7
相关论文
共 118 条
[1]  
ABDULLAH TH, 1988, J NATL MED ASSOC, V80, P439
[2]  
Ahmed N, 2001, ANTICANCER RES, V21, P3519
[3]  
Amagase H, 2001, J NUTR, V131, p955S, DOI 10.1093/jn/131.3.955S
[4]   IMPACT OF VARIOUS SOURCES OF GARLIC AND THEIR CONSTITUENTS ON 7,12-DIMETHYLBENZ[A]ANTHRACENE BINDING TO MAMMARY CELL-DNA [J].
AMAGASE, H ;
MILNER, JA .
CARCINOGENESIS, 1993, 14 (08) :1627-1631
[5]   Reversal of P-glycoprotein-mediated multidrug resistance by diallyl sulfide in K562 leukemic cells and in mouse liver [J].
Arora, A ;
Seth, K ;
Shukla, Y .
CARCINOGENESIS, 2004, 25 (06) :941-949
[6]   Induction of apoptosis by diallyl sulfide in DMBA-induced mouse skin tumors [J].
Arora, A ;
Shukla, Y .
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2002, 44 (01) :89-94
[7]   LIPID LOWERING EFFECT OF ALLICIN (DIALLYL DISULPHIDE-OXIDE) ON LONG-TERM FEEDING TO NORMAL RATS [J].
AUGUSTI, KT ;
MATHEW, PT .
EXPERIENTIA, 1974, 30 (05) :468-470
[8]   Effects of garlic on 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis [J].
Balasenthil, S ;
Arivazhagan, S ;
Ramachandran, CR ;
Nagini, S .
CANCER DETECTION AND PREVENTION, 1999, 23 (06) :534-538
[9]   ONION AND GARLIC OILS INHIBIT TUMOR PROMOTION [J].
BELMAN, S .
CARCINOGENESIS, 1983, 4 (08) :1063-1065
[10]  
Blackwood J, 1986, GARLIC NATURES ORIGI