ENZYMES IN ORGANIC-SYNTHESIS .16. ENZYME-CATALYZED LACTONIZATION OF METHYL (+/-)-(E)-3,5-DIHYDROXY-7-PHENYL-6-HEPTENOATES - A COMPARISON OF THE BEHAVIOR OF SYN-COMPOUNDS AND ANTI-COMPOUNDS

被引：18

作者：

HENKEL, B ^{[1
]}

KUNATH, A ^{[1
]}

SCHICK, H ^{[1
]}

机构：

[1] CTR SELECT ORGAN SYNTH,RUDOWER CHAUSSEE 5,O-1199 BERLIN,GERMANY

来源：

TETRAHEDRON-ASYMMETRY | 1993年 / 4卷 / 02期

关键词：

D O I：

10.1016/S0957-4166(00)82325-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

3-Hydroxy lactones with a high enantiomeric excess were obtained by the lipase-catalyzed enantioselective lactonization of racemic syn- and anti-3,5-dihydroxy carboxylic esters. The (5S)-lactones were formed predominantly from both diols with pancreatin as enzyme. The lipase from Candida sp. 382, however, catalyzed the preferential formation of the (5S)-lactone only from the syn-diol. From the anti-diol the (5R)-lactone was formed as the main enantiomer.

引用

页码：153 / 156

页数：4

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