SELECTIVE ALPHA-MONOMETHYLATION OF PHENYLACETONITRILE WITH DIMETHYL CARBONATE OR METHANOL OVER ALKALI-EXCHANGED FAUJASITES

Phenylacetonitrile was found to be selectively methylated into α-methylphenylacetonitrile (MPAN) in the vapor phase with di-methyl carbonate or methanol by using alkali ion-exchanged zeolites as catalysts. When methanol was used as a methylating agent, a 27% yield of MPAN was obtained over CsX at 623 K. Dimethyl carbonate is far more effective as a methylating agent, and the methylation proceeds at a much lower temperature. A 72% yield of MPAN was obtained over NaY at 533 K. The effects of the reaction variables are described and the raction scheme is discussed. © 1994 Academic Press, Inc.