DETERMINATION OF A NOVEL XANTHINE DERIVATIVE, MKS-213-492, IN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION

被引：2

作者：

BERLIZ, G

WINTERSTEIGER, R

PACHA, W

机构：

[1] KARL FRANZENS UNIV GRAZ,INST PHARMACEUT CHEM,A-8010 GRAZ,AUSTRIA

[2] SANDOZ PHARMA LTD,CH-4002 BASEL,SWITZERLAND

来源：

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS | 1995年 / 666卷 / 02期

关键词：

D O I：

10.1016/0378-4347(94)00592-S

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A reversed-phase liquid chromatographic method with coulometric detection has been developed for the determination of free MKS 213-492 (a novel xanthine derivative) in plasma. This method is based on a simple and rapid plasma extraction procedure using precolumn-switching. The oxidation of this pharmacologically active xanthine derivative was optimized with respect to applied potential, pH of mobile and rinsing phase and rinsing time. The detection limit for MKS 213-492 was found to be 54 pg/injection.

引用

页码：368 / 373

页数：6

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