CHROMOSOMAL ANALYSIS IN EWING SARCOMA

被引：10

作者：

CALLEN, DF ^{[1
]}

SMITH, RD ^{[1
]}

BOURNE, AJ ^{[1
]}

机构：

[1] ADELAIDE CHILDRENS HOSP, DEPT HISTOPATHOL, KING WILLIAM RD, N ADELAIDE, SA 5006, AUSTRALIA

来源：

PATHOLOGY | 1987年 / 19卷 / 01期

关键词：

D O I：

10.3109/00313028709065139

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Two cases of Ewing sarcoma were karotyped by using a fluorodeoxyuridine synchronisation procedure on short term cultures of fresh tumour material. This procedure enables rapid cytogeneic analysis of such material. Both showed relatively simple karyotypes, 48,XX,+2,+7,t(11;22)(q24;q12), ?dup(12)(q21 .fwdarw. q24) and 47,XX,i(1q),t(11;22)(q24;q12). These results further support this translocation between chromosomes 11 and 22 as a specific marker for Ewing sarcoma. Cytogenetic studies in such cases are an important adjunct to histological studies and in some cases may contribute to the resolution of the diagnosis.

引用

页码：64 / 66

页数：3

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