DEVELOPMENTAL EXPRESSION OF TRANSFORMING GROWTH-FACTORS ALPHA AND BETA IN MOUSE FETUS

被引：278

作者：

WILCOX, JN

DERYNCK, R

机构：

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1988年 / 8卷 / 08期

关键词：

D O I：

10.1128/MCB.8.8.3415

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Expression of mRNA for transforming growth factor alpha (TGF-.alpha.) and TGF-.beta.1 during the fetal development of mice was evaluated by in situ hybridization. TGF-.alpha. mRNA was detected in 9- and 10-day fetuses but was absent in older fetuses. TGF-.alpha. mRNA-containing cells were found in the placenta, otic vesicle, oral cavity, pharyngeal pouch, first and second branchial arches, and developing kidneys. mRNA for TGF-.beta.1 was present in hematopoietic cells of blood islands and capillaries and in the liver as it began to bud off on day 10 and function as a hematopoietic organ.

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页码：3415 / 3422

页数：8

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