EXAMINATION OF DES-TYROSINE1-GAMMA-ENDORPHIN ACTIVITY AT H-3-SPIROPERIDOL BINDING-SITES IN RAT-BRAIN

被引：42

作者：

PEDIGO, NW ^{[1
]}

LING, NC ^{[1
]}

REISINE, TD ^{[1
]}

YAMAMURA, HI ^{[1
]}

机构：

[1] SALK INST,NEUROENDOCRINOL LAB,LA JOLLA,CA 92112

来源：

LIFE SCIENCES | 1979年 / 24卷 / 18期

关键词：

D O I：

10.1016/0024-3205(79)90247-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Des-tyrosine1-γ-endorphin (DTγE, β-LPH 62-77) was tested for its ability to affect the binding of 3H-spiroperidol in rat corpus striatum, frontal cortex and nucleus accumbens-olfactory tubercle. 3H-Spiroperidol binds with high affinity and specificity to neuroleptic receptors in brain tissue. The inability of DTγE to inhibit specific 3H-spiroperidol binding reported here suggests that DTγE is not acting at the neuroleptic receptor labeled by 3H-spiroperidol in these regions of rat brain. © 1979.

引用

页码：1645 / 1649

页数：5

共 13 条

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